I'm so glad I ran across this jewel.  Elizabeth Cotten was an American blues and folk musician, singer, and songwriter.  Although right handed, she taught herself how to play guitar left handed. As you can see, it worked out.

Per Wikipedia:  

Elizabeth "Libba" Cotten (née Nevills) (January 5, 1893 – June 29, 1987) was an American blues and folk musician, singer, and songwriter.

A self-taught left-handed guitarist, Cotten developed her own original style. She played a guitar strung for a right-handed player, but played it upside down, as she was left-handed. This position required her to play the bass lines with her fingers and the melody with her thumb. Her signature alternating bass style has become known as "Cotten picking".

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